Effect of Different gamma-irradiation Doses on Blood Compatible Property of Polycarbonate Membranes Prepared with Chloroform

Sefercioğlu, Ruyet (2015) Effect of Different gamma-irradiation Doses on Blood Compatible Property of Polycarbonate Membranes Prepared with Chloroform. Other thesis, TED Ankara Koleji.

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In 21st century, medical treatments become one of the most essential thing for survival of patients. So, scientists have developed several synthetic materials to resolve problems in medical field. These materials include prosthesis, implements and needle catheters which are originated from polycarbonate membranes. Most of these materials are blood compatible however it is known, from patient to patient the effect of blood compatibility isn’t efficient: The aim of this study is to increase blood compatibility of polycarbonate membranes. The research question of this study is determined as “How do different -irradiation doses affect roughness and protein adsorption properties of polycarbonate membranes prepared by chloroform indicated by AFM and competitive adsorption measurements of different blood plasma proteins by batch-wise reactor?”. To deduce the effect of -irradiation on surface roughness and protein adsorption features of polycarbonate membranes, polycarbonate membranes prepared by solvent-casting technique from chloroform are tested in “Atomic Force Microscopy Studies” and “Competitive Adsorption of Blood Proteins from Plasma studies”. The experiment was conducted at Hacettepe University. At 130kGy irradiation dose, mean surface roughness of polycarbonate membranes is calculated 42.880 nm whereas untreated membranes’ mean surface roughness are calculated 28.881 nm. Protein adsorption experiments carried out with blood proteins (Serum Albumin, Fibrinogen and -globulin) demonstrated that protein adsorption significantly increased by increasing irradiation dose. Therefore It is deduced, polycarbonate membranes -irradiated at 130kGy, has a mean of competitive absorption 110.783 ng/cm2 for Serum Albumin , 60.003 ng/cm2 for fibrinogen, 49.630 ng/cm2 for -globulin. ANOVA test (p =1.56x10-25 for surface roughness, p=1.5510-39 for adsorption of Serum Albumin, p=1.23x10-49 for adsorption of Fibrinogen, 2.56x10-36 for adsorption of -globulin ) proved the sanity of data as the p values are smaller than 0.05. ANOVA test concluded; irradiation dose statistically changes surface roughness as well as irradiation dose statistically changes adsorption of different blood proteins.

Item Type: Thesis (Other)
Additional Information: IB Notu: C
Uncontrolled Keywords: polycarbonate membranes, blood compatibility
Subjects: Q Science > QH Natural history > QH301 Biology
Depositing User: Kamil Çömlekçi
Date Deposited: 27 Aug 2015 06:50
Last Modified: 27 Aug 2015 06:50
URI: http://tedprints.tedankara.k12.tr/id/eprint/675

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