Ertürk, Mine Su (2013) Investigating the effect of the stabilizer concentrations (1%, 2%, 3%, 4% and 5% PVA (polyvinyl alcohol)) on the surface properties of the nanoparticles and the drug delivery systems that are formed with the nanoparticles of 2% PLGA (poly(lactic-co-glycolic acid)), by solvent evaporation method. Other thesis, TED ANKARA COLLEGE FOUNDATION PRIVATE HIGH SCHOOL.
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Abstract
Nanotechnology aims to manipulate characteristics of matter at atomic scale in order to improve drug delivery systems. The purpose of this extended essay is to investigate how surface properties of nanoparticles and drug delivery sytems of these molecules are affected of the concentration of the stabilizer, used during the preparation. The research question is "How does changing the concentration of the stabilizer affect the surface properties of the nanoparticles and the drug delivery systems that are formed with the nanoparticles of 2% PLGA (poly(lactic-co-glycolic acid)) and the stabilizer concentrations of 1%, 2%, 3%, 4% and 5% PVA (polyvinyl alcohol), by solvent evaporation method?". The hypothesis states that there will be significant difference between the means of sizes and zeta potentials of nanoparticles that are produced with varying PVA concentrations. Thus, it will be concluded that drug delivery systems will have variety, as well. So as to verify the hypothesis, nanoparticles of PLGA are going to be prepared by solvent evaporation method where PVA concentration is going to be the independent variable. Solutions containing PLGA and PVA are mixed and the solvent is evaporated by stirring at high rates in this method. Then, the particles are analysed with a software programme and data of size and zeta potential are compared. The results illustrated that mean size and zeta potential values of varying concentrations showed significant differences. Therefore, the biocompatibilities of nanoparticles can be altered by changing the stabilizer concentration.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | Supervisor : Fuat İsmet ŞİŞMAN, IB Notu: A |
| Uncontrolled Keywords: | Nanotechnology, nanoparticles, drug delivery sytems |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Depositing User: | Users 114 not found. |
| Date Deposited: | 18 Sep 2013 06:23 |
| Last Modified: | 18 Sep 2013 06:23 |
| URI: | http://tedprints.tedankara.k12.tr/id/eprint/385 |
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