Yıldırım, Alperen Kutay (2012) IN VITRO EFFECTS OF LEAD OXIDE ON THE HUMAN ERYTHROCYTE. Other thesis, TED Ankara College Foundation High School.

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Lead has no biological function; however, low, and particularly, high levels of exposure have a number of negative consequess for human healt. Despite the number of reports about lead tocicity, very little information has been obtained regarding its effects on erythrocytes. For this reason, the morphological effects of lead on human erythrociyte were investigated. Four lead and four no lead crystal glasses were bougth and divided two groups each other. After completing the decontamination process, 200 ml of blood, or water were poured into one of the four lead and no lead crystal glasses. We measured concentrations of lead that leached into water and blood that were stored in lead and no lead crystal glasses for 1-, 2-, ….and 10- day periods at room temperature. Lead concentrations in the liquid matrix were measured using atomic absorption spectroscopy. Significant amounts of lead leached into the liquid within one day; 724 µg/L in blood, 820 µg/L in water. Lead continued to leach into both blood and water with the passage of time; 1832 µg/L in blood, 1653 µg/L in water (10th day results). Lead release was less in water than blood. Light microscobic examination of peripheral blood smears from no lead glasses relevead no morphologic changes over the erythrocytes but peripheral blood smears from lead crystal glasses showed basophilic stippling. We found four basophilic stippling at 22 lead crystal glass peripheral blood smears (18%). Significant lead contamination of water was detected when it was left in lead crystal glass. If a liter of contaminated water was drunk daily, the daily intake of lead could have been as high as 1653 µg. Such a high degree of contamination could cause chronic lead poisoning and anemia. It is recommended that we should avoid all lead based glassware.

Item Type: Thesis (Other)
Additional Information: Supervisor: Mualla Şirin GÜNTÜRKÜN, IB Notu: C
Uncontrolled Keywords: biological function, human erythrociyte
Subjects: Q Science > QH Natural history > QH301 Biology
Depositing User: Kamil Çömlekçi
Date Deposited: 09 Jul 2012 11:49
Last Modified: 12 Apr 2019 09:56

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